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Department of Microbiology & Plant Pathology




       1.      NEL, L.H., DE HAAST, J. & BRITZ, T.J., 1984. Anaerobic digestion of a petrochemical   
              effluent using an upflow anaerobic sludge blanket reactor. Biotechnology Letters6, 11: 741


2.     NEL, L.H., BRITZ, T.J. & LATEGAN, P.M., 1985. The effect of trace elements on the performance efficiency of an anaerobic fixed reactor treating a petrochemical effluent. Water S.A.11, 3: 107-110.

3.      NEL, L.H. & BRITZ, T.J., 1986. The influence of different substrate pH values on the performance of a downflow anaerobic fixed bed reactor treating an acidic petrochemical effluent. Biotechnology Letters 8, 5: 293-298.

4.      NEL, L.H. & HUISMANS, H., 1990. A comparison of different cloned genome segments of epizootic haemorrhagic disease virus as serogroup-specific probes. Archives of Virology 110: 102-112.

5.      CLOETE, T.E. & NEL, L.H., 1990. A performance comparison of imported and South African manufactured microbiological culture media. South African Journal of Science 86: 19-20.

6.      VORSTER, L.L., NEL, L.H. & KOTZé, J.M., 1990. Differentiation of strains of potato virus Y affecting tobacco in South Africa. Phytophylactica22: 129-131.

7.      NEL, L.H., PICARD, L.A. & HUISMANS, H., 1991. A characterization of the nonstructural protein from which the virus-specified tubules in epizootic haemorrhagic disease virus-infected cells are composed. Virus Research18, 219-230.

8.      VENTER, E., VILJOEN, G., NEL, L.H., HUISMANS, H. & VAN DIJK, A.A., 1991. A comparison of different genomic probes in the detection of RNA in cells infected with different orbiviruses. Journal of Virological Methods 32, 171-180.

9.      NEL., L.H. & HUISMANS, H., 1991. Synthesis of the virus-specified tubules of epizootic haemorrhagic disease virus using a baculovirus expression system. Virus Research19, 139-152.

10. VAN STADEN, V., THERON, J., GREYLING, B.J., HUISMANS, H. & NEL, L.H., 1991. A comparison of the nucleotide sequences of cognate NS2 genes of different orbiviruses. Virology 185, p 500-504.

11. COOK, G., KOTZé, J.M. & NEL, L.H., 1994. Double-stranded RNA in avocado originates from the plant genome. Plant Pathology. 43, p 913-916.

12.  NEL, L.H., THOMSON, G.R. & VON TEICHMAN, B., 1994. Molecular epidemiology of rabies virus in South Africa. Onderstepoort Journal of Veterinary Research. 60, 4 p 301-306.

13.  MONASTYRSKAYA, K., BOOTH, T., NEL, L.H. & ROY, P., 1994. Mutation of either of two cysteine residues, or deletion of the amino or carboxy termini of a nonstructural protein NS1 of bluetongue virus abrogates virus-specified tubule formation in insect cells. Journal of Virology, Vol. 68, 4 p 2169-2178.

14. THERON, J., UITENWEERDE, J.M., HUISMANS, M. & NEL, L.H. 1994. Comparison of the expression and phosphorylation of the nonstructural protein NS2 of three different Orbiviruses: Evidence for the involvement of an ubiquitous cellular kinase. Journal of General Virology 75, p 3401-3411.

15. VON TEICHMAN, B.F., THOMSON, G.R., MEREDITH, C.D. & NEL, L.H., 1995. Molecular epidemiology of rabies virus in South Africa: Evidence for two distinct virus groups. Journal of General Virology 76, p 73-82.

16. SWANEPOEL, A. & NEL, L.H. 1995. Epidemiological aspects of cucumber mosaic virus on flue-cured tobacco in South Africa.African Plant Protection 1, p 13-18.

17. THERON, J., HUISMANS, H. & NEL, L.H., 1996. Identification of a short domain within the nonstructural protein NS2 of Epizootic haemorrhagic disease virus that is important for single strand RNA-binding activity. Journal of General Virology 77, p 129-137.

18. THERON, J., HUISMANS, H. & NEL, L.H., 1996. Site-specific mutations in the NS2 protein of epizootic haemorrhagic disease virus markedly affect the formation of cytoplasmic inclusion bodies. Archives of Virology141. p 1143-1151.

19. MEREDITH, C.D., NEL, L.H. & VON TEICHMAN, B.F., 1996. A further isolation of Mokola virus from South Africa.The Veterinary Record138 (5), p119-120.

20. THERON, J. & NEL, L.H., 1997. Stable protein-RNA interaction involves the terminal domains of bluetongue virus mRNA, but not the terminally conserved sequences. Virology 229, p 134-142.

21. DU PLESSIS, M. & NEL, L.H., 1997. Comparative sequence analysis and expression of the M6 gene, encoding the outer capsid protein VP5 of African horsesickness virus serotype nine. Virus Research 47, p 41- 49.

22. NEL, L.H., JACOBS, J., JAFTHA, J. & MEREDITH, C., 1997. Natural spillover of distinctly canidae-associated biotype of rabies virus into an expanded wildlife host range in southern Africa. Virus Genes 15: 1, p 79 - 82.

23. CLOETE, T.E., DA SILVA, E. & NEL, L.H., 1998. Removal of waterborne human enteric viruses and coliphages using oxidised coal. Current Microbiology 37, p23-27.

24. NEL, L.H., BINGHAM, J., JACOBS, J.A. & JAFTHA, J.B. 1998. A nucleotide-specific polymerase chain reaction assay to differentiate rabies virus biotypes in South Africa. Onderstepoort Journal of Veterinary Research 65, 297-303.

25. MEYER, L., WEHNER, F.C., NEL, L.H. & CARLING, D.E., 1998. Characterization of the crater disease strain of Rhizoctonia solani. Phytopathology 88, p366-371.

26. VAN RENSBURG, H.G., & NEL, L.H., 1999. Characterization of the structural-protein-coding region of foot-and-mouth disease virus (FMDV) serotype SAT2. Virus Genes 19 (3): 229-233.

27. HOFFMEYR, M., BINGHAM, J., LANE, E.P., IDE, A. & NEL, L.H., 2000. Rabies in wild dogs (Lycaon Pictus) in the Madikwe game reserve, South Africa. Veterinary Record 146, 50-52.

28. VAN MARLé-KöSTER, E. & NEL, L.H., 2000. Genetic characterization of native Southern African chicken populations: evaluation and selection of polymorhic microsatellite markers. South African Journal of Animal Science 30, 1-6.

29. NEL, L.H., JACOBS, J.A., JAFTHA, J.B., VON TEICHMAN, B.F., & BINGHAM, J., 2000. New cases of Mokola virus infection in South Africa: A genotypic comparison of southern African isolates. Virus Genes 20: 2, 103-106.

30. BINGHAM J., JAVANGE, S., SABETA, C., WANDELER A.I., & NEL, L.H., 2001. Report of isolations of unusual lyssaviruses (rabies and Mokola virus) identified retrospectively from Zimbabwe. Journal of the South African Veterinary Association 72 (2): 92-94.

31. HEATH, L.E., VAN RENSBURG, H.G., VOSLOO, W., & NEL, L.H., 2001. Analyses of the 3A non-structural-protein coding regions of foot-and-mouth disease virus isolates from Africa. Onderstepoort Journal of Veterinary Research 68: 253-262.

32. VAN DER WALT, J.M., NEL, L.H., & HOELZEL, A.R. 2001. Characterization of major histocompatibility complex DRB diversity in the endemic South African antelope Damaliscus pygargus: a comparison in two subspecies with different demographic histories. Molecular Ecology 10: 1679-1688.

33. BARTIE, C., VENTER, S.N., & NEL, L.H., 2001. Evaluation of detection methods for Legionella species using seeded water samples. Water SA 27 (4): 523-528.

34. BASTOS, A.D.S., HAYDON, D.T., FORSBERG, R., KNOWLES, N.J., ANDERSON, E.C., BENGIS, R.G., NEL, L.H., & THOMSON G.R., 2001. Genetic heterogeneity of SAT-1 type foot-and-mouth disease viruses in southern Africa. Archives of Virology 146: 1537-1551.

35. ESPACH, A., ROMITO, M., NEL, L.H., & VILJOEN, G.J., 2002. Development of a diagnostic one-step RT-PCR assay for the detection of Rift Valley Fever Virus in infected animals. Onderstepoort Journal of Veterinary Research, 69: 247-252.

36. HESTER VAN RENSBURG, DANIEL HAYDON, FOURIE JOUBERT, ARMANDA BASTOS, LIVIO HEATH and LOUIS NEL., 2002. Genetic heterogeneity in the foot-and-mouth disease virus Leader and 3C proteinases. Gene, Vol. 289 (1-2) (2002) pp. 19-29

37. BARTIE, C., VENTER, S.N., & NEL, L.H., 2003. Identification methods for Legionella from environmental samples. Water Research, Volume 37, Issue 6, pp. 1362-1370.

38. Gayo, V., Romito, M., Nel, L.H., Solari, M.A., and Viljoen, G.J., 2003. PCR-based detection of the transovarial transmission of Uruguayan Babesia bovis and Babesia bigemina vaccine strains. Onderstepoort Journal of Veterinary Research, 70 pp 197-204.

39. SABETA, C.T., BINGHAM, J & NEL, L.H., 2003. Molecular epidemiology of canine rabies in Zimbabwe and South Africa. Virus Research, Vol 91/2 pp 203 - 211.

40. Van Marle-Koster, E and Nel, L.H., 2003. Genetic markers and their application in livestock breeding in South Africa: A review. South African Journal of Animal Science, Vol 33 pp 1-10.

41. L. H. Nel, M. Niezgoda, C. A. Hanlon, P. A. Morril, P. A. Yager and C. E. Rupprecht., 2003. A comparison of DNA vaccines for the rabies-related virus, Mokola. Vaccine, Volume 21, pp. 2589-2597.

42. Markotter, W., Theron, J., and Nel, L. H., 2004. Segment-specific inverted repeat sequences in bluetongue virus mRNA are required for interaction with the virus non-structural protein NS2. Virus Research,105, 1-9.

43. Hofmeyr, M., Hofmeyr, D., Nel, L. H., and Bingham, J., 2004. A second outbreak of rabies in African wild dogs (Lycaon pictus) in Madikwe Game Reserve, South Africa, demonstrating the efficacy of vaccination against natural rabies challenge. Animal Conservation, 7, 193-198.

44. L. H. Nel, C. T. Sabeta, B. von Teichman, J. B. Jaftha, C. E. Rupprecht and J. Bingham. 2005. Mongoose rabies in southern Africa: a re-evaluation based on molecular epidemiology. Virus Research, Vol 109 (2) pp 165-173.

45. Louis H Nel. 2005. Vaccines for lyssaviruses other than rabies. Expert Reviews of Vaccines, Vol 4 (4) pp 533-540.

46. W. Markotter, J. Randles, C.E. Rupprecht, C.T. Sabeta, A.I. Wandeler, P.J. Taylor and L. H. Nel. 2006. Recent Lagos bat virus isolations from bats (suborder Megachiroptera) in South Africa. Emerging Infectious Diseases, Vol 12 (3) pp 504-506.

47. Karen Mansfield, Lorraine McElhinney, Otto Hubschle, Felix Mettler, Claude Sabeta, Louis H. Nel and Anthony R. Fooks. 2006. A molecular epidemiological study of rabies epizootics in kudu (Tragelaphus strepsiceros) in Namibia. BMC Veterinary research, 13; 2 (1):2.

48. W. Markotter, I. Kuzmin, C.E. Rupprecht, J. Randles, C.T. Sabeta, A.I. Wandeler and L.H. Nel. Isolation of Lagos bat virus from water mongoose. Emerging Infectious Diseases, Vol 12 (12) pp 1913 - 1918.

49. Cloete, T.E., Nel, L.H. and Theron, J (2006). Biotechnology in South Africa. Trends in Biotechnology; doi: 10.1016/jtibtech.2006.10.009.

50. Paweska, J.T., Blumberg, L.H., Liebenberg, C., Hewlett, R.H., Grobbelaar, A.A., Leman, P.A., Croft, J.E., Nel, L.H., Nutt, L.,& Swanepoel, R. 2006. Fatal rabies-related Duvenhage virus infection in South Africa. Emerging Infectious Diseases, 12 (12) 1961-1963.

51. WALLACE D.B., WEYER J., NEL L.H. AND VILJOEN G.J. 2007. Improved method for the generation and selection of homogeneous lumpy skin disease virus (SA-Neethling) recombinants. J Virol Methods. 146, 52-60

52. SABETA C.T., MANSFIELD K.L., MCELHINNEY L.M., FOOKS A.R. AND NEL L.H. 2007. Molecular epidemiology of rabies in bat-eared foxes (Otocyon megalotis) in South Africa. Virus Res. 129, 1-10

53. COETZEE P. AND NEL L.H. 2007. Emerging epidemic dog rabies in coastal South Africa: a molecular epidemiological analysis. Virus Res. 126(1-2):186-95.

54. WEYER J., RUPPRECHT C.E., MANS J., VILJOEN G.J. AND NEL L.H. 2007. Generation and evaluation of a recombinant modified vaccinia virus Ankara vaccine for rabies. Vaccine 25 (21):4213-22.

55. SABETA C.T., MARKOTTER W., MOHALE D.K., SHUMBA W., WANDELER A.I., AND NEL L.H. 2007. Mokola virus in domestic mammals, South Africa. Emerg Infect Dis. 13: 1371-1373.

56. COHEN C., SARTORIUS B., SABETA C., ZULU G., PAWESKA J., MOGOSWANE M., SUTTON C., NEL LH., SWANEPEOL R. 2007. Epidemiology and Viral Molecular virus characterization of Reemerging Rabies, South Africa. Emerging Infectious Diseases: 13:12: 1879-1886.

57. COETZEE P., WEYER J., PAWESKA J.T., BURT F.J., MARKOTTER W. AND NEL L.H. 2007. Use of a molecular epidemiological database to track human rabies case histories in South Africa. Epidemiol Infect. 26:1-7.

58. WEYER J., KUZMIN I.V., RUPPRECHT C.E., AND NEL L.H. 2007.Cross-protective and cross-reactive immune responses to recombinant vaccinia viruses expressing full-length lyssavirus glycoprotein genes. Epidemiol. Infect. 22:1-9.

59. NEL L.H. AND RUPPRECHT, C.E. 2007. “Emergence of Lyssaviruses in the Old World: The Case of Africa.” In Current Topics in Microbiology and Immunology: Wildlife and Emerging Zoonotic Diseases: The Biology, Circumstances and Consequences of Cross-Species Transmission. J Childs (ed) Springer-Verlag, 161-193. Heidelberg, Springer Berlin. pp161-193

60. NEL L.H. AND WEYER J. 2007 Animal Viruses Pathogenic for Humans. In: ENCYCLOPEDIA OF LIFE SCIENCES. John Wiley & Sons, Ltd: Chichester [DOI:10.1002/9780470015902. a0001079.pub2]

61. NEL L.H. AND MARKOTTER W. 2007. Lyssaviruses. Critical Reviews in Microbiology, 33:301-324

62. BOtha EM, Markotter W, Wolfaardt M, Paweska JT, Swanepoel R, Palacios G,, Nel LH, Venter, M. 2008. Genetic Determinants of Virulence in Pathogenic Lineage II West Nile Virus Strains. Emerging Infectious Diseases Vol 14:222-230.

63. CA le Roux., LH Nel. and JT Paweska. 2008. Development and evaluation of a real-time reverse transcription-loop-mediated isothermal amplification assay for rapid detection of Rift Valley fever virus in clinical specimens. Journal of Clinical Microbiology. Doi:10.1128/JCM.01412-08

64. Coetzee P, Weyer J, Paweska JT, Burt FJ, Markotter W, Nel LH. 2008. Use of a molecular epidemiological database to track human rabies case histories in South Africa. Epidemiology and Infection. 2008; 136 (9): 1270-6.

65. CT Sabeta, W Shumba, DK Mohalea, JM Miyena, AI Wandeler and LH Nel. 2008. Mongoose rabies and the African civet in Zimbabwe. The Veterinary Record, November 2008: 580.

66. E. van Marle-Köster, C.A. Hefer, L.H. Nel and M.A.M. Groenen. 2008. Genetic diversity and population structure of locally adapted South African chicken lines: Implications for conservation. South African Journal of Animal Science, 2008: vol 38 (4) pp271-281.

67. J. B. Meyer, G. G. F. Kasdorf, L. H. Nel and G. Pietersen. 2008. Transmission of Activated-Episomal Banana streak OL (badna)virus (BSOLV) to cv. Williams Banana (Musa sp.) by Three Mealybug Species. Plant Disease. August 2008, 92 (8): 1158-1163

68. LAMPRECHT, R.L., PIETERSEN, G. KASDORF, G.G.F., and NEL, L.H., 2008 Characterisation of a proposed Nucleorhabdovirus new to South Africa. European Journal of Plant Pathology. DOI 10.1007/s10658-008-9339-5

69. Louis Nel, Kevin Le Roux, and Ronald Atlas. 2008. Rabies Control Program in South Africa. Microbe, In Press, American Soc for Microbiol.

70. Markotter W; Kuzmin I; Rupprecht C E and Nel L H. 2008. Phylogeny of Lagos bat virus: challenges for lyssavirus taxonomy. Virus Research. 2008; 135 (1): 10-21.

71. Markotter, W., Van Eeden, C., Kuzmin, I., Rupprecht, C.E., Paweska, J.T., Swanepoel, R., Fooks, A.R., Sabeta, C.T., Cliquet, F., and Nel, L.H. 2008. Epidemiology and pathogenicity of african bat lyssaviruses. Developments in Biologicals 2008; 131; 317-25.

72. MEYER, J.B., KASDORF, G.G.F., NEL, L.H. & PIETERSEN, G. , 2008 Transmission of Activated-Episomal Banana Streak OL (badna)virus (BSOLV) to cv. Williams banana (Musa sp.) by Three Mealybug Species. Plant Disease 2008 92 (8):1158-1163

73. R. L. Lamprecht, G. Pietersen, G. G. F. Kasdorf and L. H. Nel. 2008. Characterisation of a proposed Nucleorhabdovirus new to South Africa. European Journal of Plant Pathology, 10.1007/s10658-008-9339-5.

74. Rupprecht CE…Nel LH et al. 2008. Can Rabies be Eradicated? Developments in Biologicals. 131: 95-121.

75.  Markotter W, Kuzmin I, Rupprecht CE and Nel LH. 2009. Lagos bat virus virulence by the peripheral route. Epidemiology and Infection. 137:1155-1162

76.  Markotter W, York D, Sabeta CT, Shumba W, Zulu G, Le Roux K, Nel LH. 2009. Evaluation of a rapid immunodiagnostic test kit for detection of African lyssaviruses from brain material. Onderstepoort Journal of Veterinary Research. 76:257-262.

77.  R.L. Lamprecht, G. Pietersen, G.G.F. Kasdorf and L.H. Nel. 2009. Characterisation of a proposed Nucleorhabdovirus new to South Africa. Eur J Plant Pathol, 123: 105-110.

78.  C. Malerczyk, L.H. Nel, D. Gniel and L. Blumberg. 2010. Rabies in South Africa and the FIFA Soccer World Cup. Human Vaccines. 11713.

79.  Coertse J, Weyer J, Nel L.H., and Markotter W. 2010. Improved PCR methods for detection of African rabies and rabies-related lyssaviruses. Journal of Clinical Microbiology. 48 (11): 3949-3955.

80.  Malerczyk, C., Nel, L.H. and Blumberg, L. 2010. Rabies in South Africa and the FIFA Soccer World Cup. Traveler’s awareness for an endemic but neglected disease. Human Vaccines, 6:5, 1-5.

81.  Van Zyl N, Markotter W, and Nel LH. 2010. Evolutionary history of African mongoose rabies. Virus Research. 150: 93-102

82.  Weyer J, Szmyd-Potapczuk AV, Paweska JT, Blumberg LH, Leman PA, Markotter W, Swanepoel R, Nel LH. 2010.  Epidemiology of human rabies in South Africa, 1983-2007. Virus Research. doi:10.1016/j.virusres. 2010.10.023