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Department of Nuclear Medicine

Recent Research Publications



Sathekge, Mike, Alicia McFarren, and Ekaterina Dadachova. Role of nuclear medicine in neuroHIV: PET, SPECT, and beyond." Nuclear medicine communications (2014).

Sathekge, Mike. Differentiation of HIV-associated lymphoma from HIV-reactive adenopathy using quantitative FDG-PET and symmetry. European journal of nuclear medicine and molecular imaging 41, no. 4 (2014): 593-595.

Ebenhan, Thomas, Jan Rijn Zeevaart, Jacobus D. Venter, Thavendran Govender, Gert H. Kruger, Neil V. Jarvis, and Mike M. Sathekge. Preclinical Evaluation of 68Ga-Labeled 1, 4, 7-Triazacyclononane-1, 4, 7-Triacetic Acid-Ubiquicidin as a Radioligand for PET Infection Imaging. Journal of Nuclear Medicine 55.2 (2014): 308-314.

Van de Wiele, C., M. M. Sathekge, and A. Maes. Targeting monocytes and macrophages by means of SPECT and PET. The quarterly journal of nuclear medicine and molecular imaging (2014).

Mees, G., Sathekge, M., Maes, A., & Van de Wiele, C. (2014). Radiolabelled probes targeting tumor hypoxia for personalized medicine. Current pharmaceutical design, 20(14), 2308-2318.

Sathekge, Mike, Christophe Van de Wiele, and Alberto Signore. "Nuclear Medicine Imaging of Tuberculosis and Human Immunodeficiency Virus." Diagnostic Imaging of Infections and Inflammatory Diseases: A Multidisciplinary Approach (2014): 255-272.

Ebenhan, Thomas, Olivier Gheysens, Hendrick Gert Kruger, Jan Rijn Zeevaart, and Mike Machaba Sathekge. Antimicrobial Peptides: Their Role as Infection-Selective Tracers for Molecular Imaging. BioMed Research International 2014 (2014).

Vorster, M., Maes, A., Jacobs, A., Malefahlo, S., Pottel, H., Van de Wiele, C., & Sathekge, M. M. (2014). Evaluating the possible role of 68Ga-citrate PET/CT in the characterization of indeterminate lung lesions. Annals of nuclear medicine, 1-8.

Vorster, M., Maes, A., Van de Wiele, C., & Sathekge, M. M. (2014). 68Ga-citrate PET/CT in Tuberculosis: A pilot study. The quarterly journal of nuclear medicine and molecular imaging

Vorster, M., Sathekge, M. M., & Bomanji, J. (2014). Advances in imaging of tuberculosis: the role of 18F-FDG PET and PET/CT. Current opinion in pulmonary medicine, 20(3), 287-293.

Huic, D., Almeida, P., Oh, G., Pruzzo, R., Kostadinova, I., Vorster, M., ... & Pascual, T. N. (2014, May). The added value of SPECT/CT in sentinel node identification in melanoma patients-A prospective multicenter IAEA study. In Society of Nuclear Medicine Annual Meeting Abstracts (Vol. 55, No. Supplement 1, p. 654).

Vorster, M., Nyakale, N., & Sathekge, M. (2014). Impulsivity Imaging. In PET and SPECT in Psychiatry (pp. 583-620). Springer Berlin Heidelberg.

Zinn, C., Vorster, M., & Sathekge, M. M. Spinal Tuberculosis Evaluated by Means of 18F-FDG PET/CT: Pilot Study. The Open Nuclear Medicine Journal, 2014, 6, 6-11

Kruse, V., C. Van de Wiele, M. Borms, A. Maes, Hans Pottel, M. Sathekge, and V. Cocquyt. "CA 15.3 measurements for separating FDG PET/CT positive from negative findings in breast carcinoma recurrence. Factors influencing the area under the ROC curve." Nuklearmedizin. Nuclear medicine 53, no. 4 (2014): 131-138.

Clauss, Ralf P., Max Zöttl, and Mike Sathekge. Imaging of the Antidepressant Drug Response Using SPECT and PET. PET and SPECT in Psychiatry. Springer Berlin Heidelberg, 2014. 325-345.


Sathekge, M. Targeted radionuclide therapy. Continuing Medical Education. 2013:31.(8): 289-294. 
Vorster M, Maes A, Van deWiele C, Sathekge M. Gallium-68: a systematic review
of its nononcological applications. Nucl Med Commun. 2013 Sep;34(9):834-54. 
Hatutale A, Vorster M, Ankrah AO, Rheeder P, Sathekge MM. Association of
hemodynamic response during dipyridamole stress testing with (99m)Tc-MIBI SPET myocardial perfusion image findings. Hell J Nucl Med. 2013 Oct 2. doi:pii:
s002449910096. [Epub ahead of print] 
Sathekge M, Wagener J, Smith SV, Soni N, Marjanovic-Painter B, Zinn C, Van de
Wiele C, D'Asseler Y, Perkins G, Zeevaart JR. Biodistribution and dosimetry of
195mPt-cisplatin in normal volunteers. Imaging agent for single photon emission computed tomography. Nuklearmedizin. 2013 Oct 10;52(6). [Epub ahead of print].
Iagaru A, Mosci C, Dick DW, Sathekge M, Lapa P, de Lima JM, Gambhir SS.
Combined (18)F-fluoride and (18)F-FDG PET/CT: a response based on actual data from prospective studies. Eur J Nucl Med Mol Imaging. 2013 Dec;40(12):1922-4. 
Mees G, Sathekge M, Maes A, Yves D'Asseler EY, Wiele CV. Radiolabelled probes
targeting tumor hypoxia for personalized medicine. Curr Pharm Des. 2013 Sep 11.
[Epub ahead of print] 
Bunschoten A, Welling M, Termaat F, Sathekge M, van Leeuwen FW. Development
and prospects of dedicated tracers for the (molecular) imaging of bacterial
infections. Bioconjug Chem. 2013 Nov 7. [Epub ahead of print] 
Iagaru A, Mittra E, Mosci C, Dick DW, Sathekge M, Prakash V, Iyer V, Lapa P,
Isidoro J, de Lima JM, Gambhir SS. Combined 18F-fluoride and 18F-FDG PET/CT
scanning for evaluation of malignancy: results of an international multicenter
trial. J Nucl Med. 2013 Feb;54(2):176-83. 
Perkins AC, Mshelia DS, Symonds ME, Sathekge M. Prevalence and pattern of
brown adipose tissue distribution of 18F-FDG in patients undergoing PET-CT in a 
subtropical climatic zone. Nucl Med Commun. 2013 Feb;34(2):168-74.
Van de Wiele C, Kruse V, Smeets P, Sathekge M, Maes A. Predictive and
prognostic value of metabolic tumour volume and total lesion glycolysis in solid
tumours. Eur J Nucl Med Mol Imaging. 2013 Jan;40(2):290-301. 


Sathekge M, Maes A, Van de Wiele C. FDG-PET imaging in HIV infection and
tuberculosis. Semin Nucl Med. 2013 Sep;43(5):349-66.



Masekela R, Gongxeka H, Green RJ, Sathekge M. Positron emission tomography in the prediction of inflammation in children with human immunodeficiency virus related bronchiectasis. Hell J Nucl Med. 2012 Jan-Apr;15(1):23-7.


Alexanderson, Better, N. Bouyoucef, S.-E. Dondi, M. Dorbala, S. El-Haj, N. Giubbini, R. Spedali Civili di Brescia, Italy Keng, F Kumar, A. Marcassa, C. Massardo, T. Universidad de Chile, Chile Milan, E Mut, F Obaldo, J., Philippines Paez, D. Peix, A. Thomas, G Vitola, J. Vorster, M. Nuclear Cardiology: Guidance and Recommendations for Implementation in Developing Countries IAEA Human Health Series 23 Subject Classification 0100-Life Sciences. IAEA. STI/PUB/1566 (ISBN: 978-92-0-131710-0). ISSN 2075-3772

Ankrah A, Buscombe J, Sathekge MM. Association between plasma homocysteine and
myocardial SPECT abnormalities in patients referred for suspected myocardial ischaemia. Cardiovasc J Afr. 2012 Jul;23(6):313-7.

Nyakale NE, Clauss RP, Nel HW, Sathekge MM. Blood-brain barrier integrity in a
zolpidem-responder patient. S Afr Med J. 2012 Jul 31;102(10):790-1.

Better N, Karthikeyan G, Vitola J, Fatima A, Peix A, Novak MD, Soares J Jr,
Bien VD, Briones PO, Vangu M, Soni N, Nguyen A, Dondi M. Performance of rest myocardial perfusion imaging in the management of acute chest pain in the emergency room in developing nations (PREMIER trial). J Nucl Cardiol. 2012 Dec;19(6):1146-53.

Madiba TE, Awotedu AA, du Plessis D, Nchabeleng M, Sathekge MM, Velaphi SC,The Hamilton Naki Clinical Scholarship, 2007 - 2011. SAMJ 2012; 102: 20.

Mshelia DS, Hatutale AN, Mokgoro NP, Nchabaleng ME, Buscombe JR, Sathekge MM.
Correlation between serum calcium levels and dual-phase (99m)Tc-sestamibi parathyroid scintigraphy in primary hyperparathyroidism. Clin Physiol Funct Imaging. 2012 Jan;32(1):19-24. 
Sathekge M, Maes A, D'Asseler Y, Vorster M, Van de Wiele C. Nuclear medicine imaging in tuberculosis using commercially available radiopharmaceuticals. Nucl Med Commun. 2012 Jun;33(6):581-90.

Sathekge M, Maes A, D'Asseler Y, Vorster M, Gongxeka H, Van de Wiele C. Tuberculous lymphadenitis: FDG PET and CT findings in responsive and nonresponsive disease. Eur J Nucl Med Mol Imaging. 2012 Apr 18. 
Sathekge M, Maes A, Van de Wiele C. Reply: Letter to the Editor. J Nucl Med. 2012; 53:165-166.
Zeevaart JR, Szucs Z, Pulker T, Sello T, Bracher J, Sathekge M. Biodistribution and Pharmacokinetics of I-131 Labelled 4-Iodophenylacetic Acid. Curr Radiopharm. 2012; 5: 356-362.


M Sathekge, Maes A, Kgomo M, Stoltz A, Van de Wiele C. Use of 18F-FDG PET to Predict Response to First-Line Tuberculostatics in HIV-Associated Tuberculosis. J Nucl Med. 2011 Jun;52(6):880-5.

 Z Szucs M Sathekge; J Wagener, C Wagener, JR Zeevart. SYNTHESIS OF I-131 LABELLED 4-IODOPHENYLACETIC ACID. Journal of Labelled Compounds and Radiopharmaceuticals 2011; 54 (1): 54-58.

M Vorster, M Sathekge. Detection of extensive metastases from anaplastic thyroid cancer by F-18 FDG PET/CT. The Open Nuclear Medicine Journal 2011. 3.

M Sathekge , Buscombe JR. Can positron emission tomography work in the African tuberculosis epidemic? Nucl Med Commun. 2011 Apr;32(4):241-4.

JM Warwick, M Sathekge. PET/CT scanning with a high HIV/AIDS prevalence. Transfus Apher Sci. 2011 Apr;44(2):167-72.


A. M. Katua, A. O. Ankrah, M. Vorster, A. van Gelder1, M. M. Sathekge. Optimization of Ordered Subset Expectation Maximization Reconstruction for Reducing Urinary Bladder Artifacts in Single-photon Emission Computed Tomography Imaging.W J Nucl Med 2011; 10: 3-8.

Chiacchio S, Mazzarri S, Lorenzoni A, Nyakale N, Boni G, Borsò E, Alsharif A, Grosso M, Manca G, Greco C, Volterrani D, Mariani G. Radionuclide therapy and integrated protocols for bone metastases. Q J Nucl Med Mol Imaging. 2011 Aug;55(4):431-47. Review. PubMed PMID: 21738116.


M Vorster, M Sathekge, P Rheeder. Erythromycin as an alternative to reduce interfering extra-           cardiac activity in Myocardial Perfusion Imaging. CardioVascular Journal of Africa 2010 21(3); 142-147.

M Sathekge, Maes A, Kgomo M, Van de Wiele C. Fluorodeoxyglucose uptake bylymph nodes of HIV patients is inversely related to CD4 cell count. Nucl MedCommun. 2010 Feb;31(2):137-40

M Sathekge, Maes A, Kgomo M, Stoltz A, Pottel H, Van de Wiele C. Impact of FDG PET on the management of TBC treatment. A pilot study. Nuklearmedizin.2010;49(1):35-40.

M Sathekge, Maes A, Kgomo M, Stolz A, Ankrah A, Van de Wiele C. Evaluation of glucose uptake by skeletal muscle tissue and subcutaneous fat in HIV-infectedpatients with and without lipodystrophy using FDG-PET. Nucl Med Commun. 2010; 31: 311-314 Feb 6.

M Sathekge, Maes A, Kgomo M, Stoltz A, Pottel H, Van de Wiele C . Dual time-point FDG PET-CT cannot differentiate benign from malignant solitary pulmonary nodules in a TB endemic area. SAMJ 2010; 100(9); 598-601.

M Sathekge, A Maes, H Pottel, A Soltz, C van de Wiele. FDG uptakein lymph nodes of HIV and TB patients: Implications for staging.  Quarterly Nucl Med 2010; 54 (6): 698-703.

M Sathekge. FDG PET imaging in Gynaecology. Guest Editorial. O&G Forum 2010; 20: 37-39.

Sathekge M, Ellmann A. WFNMB: Benchmarking Quality. Editorial. WJNM 2010 September; 9, Supplement 1, S1

N. Nyakale, R Clauss, W Nel, M Sathekge. Clinical and Brain SPECT scan response to zolpidem in patients after brain damage. Arzneimittelforschung. 2010;60(4):177-81.

Prior to 2010

M Sathekge, Maes A, Al-Nahhas A, Rubello D, Chiti A. What impact can fluorine-18 fluorodeoxyglucose PET/computed tomography have on HIV/AIDS and tuberculosis pandemic?. Editorial. Nucl Med Commun. 2009;30:255-7

M Sathekge, Goethals I, Maes A, van de Wiele C. Positron emission tomography in patients suffering from HIV-1 infection. Eur J Nucl Med Mol Imaging. 2009; 36: 1176-1184.

M M Sathekge. The potential of 68-Ga-labelled peptides in PET imaging of infection. Editorial. Nucl Med Comm 2008: 29; 663-5.

M M Sathekge, J Warwick, MD Vangu, A Ellmann, M Mann. A case for provision of Positron Emission Tomography in South African Public Hospital. SAMJ; 96 2006:598 - 601

T Nunan, M M Sathekge, Pioneering of Positron Emission Tomography in South Africa. Editorial. Nucl Med Comm 2007 28; 235-7.

M M Sathekge, NP Mokgoro, P Mpikashe, OE Ramafi. I-123 Uptake by intrathoracic stomach.   
Clin Nucl Med 2005: 30(1);42.

F Naude, W v Vuuren, K Venter, V pellegrin, JL Holl, M M Sathekge. Impact of scintimammography in breast cancer. SAJR; March 2006.

NE Nyakale, M Vorster, P Mpikashe, W v Vuuren, BJ Meyer, M M Sathekge. “Thymoma detection with Tc-99m MIBI SPECT/CT” Case of the Month. Applied Radiology as a Radiological In Press.

W v Vuuren, NE Nyakale, F Naude , BJ Meyer, M M Sathekge. Pheochromocytoma and Parganglioma. Two Cases. SA FAM Pract 2007; 29(5): 42-5

M Al-Makhzomi , M M Sathekge , P Seynaeve, D Nicolaij, Maes A. PET/CT positive brown tumour - a potentially misleading finding in the evaluation of a patient for malignant primary tumor or metastases. SAJR; Nov 2007

F Ismail, Z Lockhat, M Sathekge, N Khan, I van de Werke, N Adroos, D Reynders, M Kruger. Metastatic calcification as a result of extensive bone metastases in a paediatric patient with Parameningeal Embryonal Rhabdomyosarcoma. South African Journal of Radiology 2008; 12(1): 10-12.

P Mpikashe, M M Sathekge, B J Meyer. Protein-losing enteropathy demonstrated on Tc-99m HAS. South African Journal of Radiology 2008; 12(2): 36-37.